Preheat oven to 350°F (175°C). Lightly grease a 9x13-inch baking dish with cooking spray.
Cook the meat: In a skillet over medium heat, cook the ground beef (or turkey) until no longer pink. Drain excess fat.
Make the sauce: Stir in ketchup, water, brown sugar, Worcestershire sauce, mustard, garlic powder, onion powder, and salt. Let the mixture simmer for 5 minutes to meld flavors.
Mix in biscuits: Transfer the meat mixture to a large bowl. Add the quartered biscuit pieces and gently toss to coat them evenly.
Assemble the casserole: Spread the biscuit-meat mixture evenly into the prepared baking dish.
Top with cheese: Sprinkle shredded cheddar cheese evenly over the top.
Bake: Place in the oven and bake for 28 to 30 minutes, or until the biscuits are golden brown and cooked through.
Serve hot: Let cool slightly before serving, then dig into this cheesy, bubbly goodness!