Preheat oven to 300°F (150°C). Line a roasting pan or baking dish with foil.
Trim the brisket fat cap to about ¼-inch if needed. Pat dry.
In a small bowl, mix the thyme, smoked paprika, black pepper, salt, onion powder, garlic powder, cayenne pepper, and cumin to create the dry rub.
Rub the spice mixture generously over both sides of the brisket.
Place the brisket in the prepared pan, fat side up. Drizzle with Worcestershire sauce and BBQ sauce, then spread evenly with a spatula.
Cover the pan tightly with foil and roast for 2 hours without uncovering.
Remove from the oven, flip the brisket, re-cover with foil, and return to the oven. Roast for another 1½ to 2 hours, or until the brisket is fork-tender.
Transfer the brisket to a cutting board, slice against the grain, and drizzle with pan sauce before serving.